Publications with participation of the Quantitative Lipidomics Facility at the Institute of Molecular Physiology and Biotechnology of Plants (IMBIO)
Scholz P, Dabisch J, Vilchez AC, Clews AC, Niemeyer PW, Lim MSS, Sun S, Hembach L, Naganawa M, Dreier F, Blersch KF, Preuß LM, Bonin M, Lesch E, Iwai Y, Shimada TL, Eirich J, Finkemeier I, Gutbrod K, Dörmann P, Wang Y, Mullen RT, Ischebeck T (2026) Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage. New Phytol. 249, 892-916, doi:10.1111/nph.70726
Panthapulakkal Nrayanan S, Dotson BR, Noack, L, Holla S, Ren S, Dörmann P, Widell S, Persson S, Lager I, Rasmusson AG (2026) New Phytol. Arabidopsis phospholipid modifications mediate cellulose-induced resistance to a fungal peptide antibiotic by imposing cell polarity. New Phytol. 249, 975-991, doi:10.1111/nph.70721
Herbst M, König MA, Gutbrod K, Volk J, Dörmann P, Bülow MH, Engeser M (2026) Sample preparation of Drosophila melanogaster larvae for MALDI imaging. Anal. Bioanal. Chem. doi: 10.1007/s00216-025-06289-x
Gutbrod K, Dörmann P (2026) Future perspectives in mass spectrometry of plant lipids. Planta 263, 113, doi: 10.1007/s00425-026-04981-5
Shajil Das Arpita, Shajil Das Amita, Chen Z, Fink P, Peisker H, Gutbrod K, Hölzl G, Forchhammer K, Dörmann P (2026) Engineering carbon metabolism in Synechocystis sp. PCC 6803 for enhanced lipid production. Algal Res. 104795, doi: 10.1016/j.algal.2026.104795
Shoaib Y, Han R, Bhattacharyya S, Finkenauer A, Gutbrod K, Dörmann P, Kang H, Vothknecht UC, Chigri F (2026) ALKBH10B mediated epitranscriptomic regulation enhances drought tolerance of Arabidopsis thaliana via hormonal cross-talk and sustained photosynthesis. Plant Cell Reports 45, 257, doi: 10.1007/s00299-026-03951-1
Siebers M, Hölzl G, Wehler R, Lerch J, Gutbrod K, Schmidt AM, Melzer M, Meyer AJ, Dörmann P (2026) Phospholipid homeostasis and gametophyte development require the glycerophosphodiester glycerophophsodiesterases GDPD5 and GDPD6. Plant Physiol 202, kiag585, doi.org/10.1093/plphys/kiag585
Chen Z, Peisker H, Gutbrod K, Hölzl G, Dörmann P (2026) Adaptation of lipid metabolism of the polyextremophilic cyanobacterium Cyanobacterium aponinum PCC 10605 to adverse environmental conditions. BMC Plant Biol. 26, 734, doi: 10.1186/s12870-026-08797-z
Scholz P, Doner NM, Gutbrod K, Herrfurth C, Niemeyer PW, Lim MSS, Blersch KF, Schmitt K, Valerius O, Shanklin J, Feussner I, Dörmann P, Braus GH, Mullen RT, Ischebeck T (2025) Plasticity of the Arabidopsis leaf lipidome and proteome in response to pathogen infection and heat stress. Plant Physiol. 197, kiae274, doi:10.1093/plphys/kiae274
Xue H, Jaenisch J, Sasse J, McGarrigle ER, Choi EH, Louie K, Gutbrod K, Dörmann P, Northen TR, Wildermuth MC (2025) Powdery mildew induces chloroplast storage lipid formation at the expense of host thylakoids to promote spore production. Plant Cell koaf041, doi: 10.1093/plcell/koaf041
Shajil Das A, Shajil Das A, Chen Z, Peisker H, Gutbrod K, Hölzl G, Dörmann P (2025) Multifunctional acyltransferases involved in the synthesis of triacylglycerol, fatty acid phytyl esters and plastoquinol esters in cyanobacteria. Planta 261, 123, doi: 10.1007/s00425-025-04700-6
Cui J, Fassl M, Vasanthakumaran V, Dierig MM, Hölzl G, Karmainski T, Tiso T, Kubicki S., Thies S, Blank LM, Jaeger K-E, Dörmann P (2025) Biosurfactant biosynthesis by Alcanivorax borkumensis and its role in oil biodegradation. Nature Chem. Biol. 21, 1631-1641, doi: 10.1038/s41589-025-01908-1
Grabert J, Mohsen G, Diepenseifen C, Heister U, Breil, M, Rohner M, Graeff I, Kapppler J, Gutbrod K, Dörmann P, Schewe JC, Kunsorg A, Mayr A, Stroemer A, Stoppe C, Zimmer S, Hoffmann U, Duerr GC, Wittmann M, Velten M (2025) The impact of preexisting omega-3 fatty acid serum levels on outcomes following out-of-hospital cardiac arrest: A comprehensive investigation. Life Sci 377, 123770, doi: 10.1016/j.lfs.2025.123770
Wehler R, Hoppe N, Gutbrod K, Zeisler-Diehl VV, Peisker H, Gisch N, Hofvander P, Lager I, Schreiber L, Dörmann P (2025) Identification of 1,6-hexadecanediol and its wax diesters in chloroplasts of Nicotiana benthamiana. Planta 262, 117, doi:10.1007/s00425-025-04833-8
Loha A, Bouziri S, Aparicio Chacon MV, Abriata LA, Gutbrod G, Dörmann P, Kemppainen M, Martin F, Poirier Y (2025) Laccaria bicolor adapts to phosphate deficiency at the developmental, transcriptional and metabolic levels. Mycorrhiza 35, 71, doi:10.1007/s00572-025-01236-1
Romer J, Gutbrod K, Schuppener, A, Melzer M, Müller-Schüssele, SJ, Meyer A, Dörmann P (2024) Tocopherol and phylloquinone biosynthesis in chloroplasts requires the phytol kinase VITAMIN E PATHWAY GENE5 (VTE5) and the farnesol kinase (FOLK). Plant Cell 36, 1140-1158, koad316, doi:10.1093/plcell/koad316
Qin P., Chen P., Zhou Y., Zhang W., Zhang Y, Xu J, Gan L., Liu Y, Romer J, Dörmann P., Cahoon E.B., Zhang C. (2024) Vitamin E biofortification: enhancement of seed tocopherol concentrations by altered chlorophyll metabolism. Front. Plant Sci. 15:1344095, doi:10.3389/fpls.2024.1344095
John A, Krämer M, Lehmann M, Kunz H-H, Aarabi F, Alseekh S, Fernie A, Sommer F, Schroda M, Zimmer D, Mühlhaus T, Peisker H, Gutbrod K, Dörmann P, Neunzig J, Philippar K, H Neuhaus HE (2024) Degradation of FATTY ACID EXPORT PROTEIN1 by RHOMBOID-LIKE PROTEASE11 contributes to cold tolerance in Arabidopsis. Plant Cell 36, 1937-1962, koae011, doi:10.1093/plcell/koae011
Gutbrod P, Pottier D, Shirvani S, Gutbrod K, Djen-Nyami F, Ngoudjede RE, Ngando-Ebonge G, Dörmann P (2024) Unusual vitamin E provile in the oil of a wild African oil palm tree (Elaeis guineensis Jacq.) enhances oxidative stability of provitamin A. Front. Plant Sci. 15:1400852. doi:10.3389/fpls.2024.1400852
Liu C, Hatzianestis IH, Pfirrmann T, Reza SH, Minina EA, Moazzani A, Stael S, Gutierrez-Beltran E, Pitsili E, Dörmann P, D'Andrea S, Gevaert K, Romero-Campero F, Ding P, Nowack MK, van Breuegem F, Jones JDG, Bozhkov PV, Moschou PN (2024) Seed longevity is controlled by metacaspases. Nat. Comm. 15, 6748, doi:10.1038/s41467-024-50848-2
Obers A, Poch T, Rodrigues G, Christo SN, Gandolfo LC, Fonseca R, Zaid A, Kuai JEY, Lai H, Zareie P, Ykou MH, dryburgh L, Blum TN, Dosser J, Buquicchio FA, Lareau CA, Walsh C, Judd L, Theodorou MR, Gutbrod K, Dörmann P Kingham J, Stinear T, Kallies A, Schroeder J, Mueller SN, Park SL, Speed TP, Satpathy AT, Phan TG, Wilhelm C, Zaph C, Evrard M, Mackay LK (2024) Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency. Immunity 57, P2615-2633.E10, doi:10.1016/j.immuni.2024.09.015
Gutbrod K., Romer J., Dörmann P. (2023) Analysis of isoprenyl-phopshates by liquid chromatography-mass spectrometry. Meth. Enzymol. 683, 171-190, doi:10.1016/bs.mie.2022.08.026
Zhang Q., Boundjou N., Jia L., Wang X., Zhou L., Peisker H., Li Q., Guo L., Dörmann, P., Lyu D., Zhou Y. (2023) Cytidinediphosphate diacylglycerol synthase is essential for mitochondrial structure and energy production in Arabidopsis thaliana. Plant J. 114, 338-354, doi.org/10.1111/tpj.16139
Cabron A.S., Borgmeyer U., Richter, J., Peisker H., Gutbrod K., Dörmann P., Capell A., Damme M. (2023) Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration. Acta Neuropahtol. Commun. 11, 1-13, doi:10.1186/s40478-023-01510-3
Müller Y., Patwari P., Stöcker T., Zeisler-Diehl V., Steiner U., Campoli C., Grewe L., Kuczkowska M., Marita Dierig M., Jose S., Hetherington A.M., Acosta I.F., Schoof H., Schreiber L., Dörmann P. (2023) Isolation and characterization of the gene HvFAR1 encoding acyl-CoA reductase from the cer-za.227 mutant of barley (Hordeum vulgare) and analysis of the cuticular barrier functions. New Phytol. 239, 1903-1918, doi:10.1111/nph.19063
Hanke W., Alenfelder J., Liu J., Gutbrod P., Kehraus S., Crüsemann M., Dörmann M., Kostenis E., Scholz M., König G.M. (2023) The bacterial Gq signal transduction inhibitor FR900359 impairs soil-associated nematodes. J. Chem. Ecol. doi:10.1007/s10886-023-01442-1
Hofmann D., Thiele B., Siebers M., Rahmati M., Schütz V., Jeong S., Bigler L., Held F., Wu B., Babic N., Kovacic F., Hamacher J., Hölzl G., Dörmann P., Schulz M. (2023) Implications of below-ground allelopathic interactions of Camelina sativa and microorganisms for phosphate availability and habitat maintenance. Plants 12, 2815, doi:10.3390/plants12152815
Arndts K., Kegele J., Massarani A.S., Ritter M., Wagner T., Pfarr K., Lämmer C., Dörmann P., Peisker H., Menche D., Al-Bahra M., Prazeres da Costa C., Schmutzhard E., Matuja W., Hoerauf A., Layland-Heni L.E., Winkler A.S. (2023) Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns. Plos Negl. Trop. Dis., doi:10.1371/journal.pntd.0011503
Düsing P., Heinrich N.N., Al-Kassou B., Gutbrod K., Dörann P., Nickenig G., Jansen F., Zietzer A. (2023) Analysis of circulating ceramides and hexosylceramides in patients with coronary artery disease and type II diabetes mellitus. BMC Cardiovasc. Disord. 23, 454, doi:10.1186/s12872-023-03454-x
Liu C., Mentzelopoulou A., Papagavril F., Ramachandran P., Pernaki A., Claus L., Barg S., Dörmann P., Jaillais Y., Johnen P., Russinova E., Gizeli E., Schaaf G., Moschou P.N. (2023) SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis. Plos Biol. 21, e3002305, doi:10.1371/journal.pbio.3002305
Yang W., Gutbrod P., Gutbrod K., Peisker H., Song X., Falz A.-L., Meyer A.J., Dörmann P. (2022) 2-Hydroxy-phytanoyl-CoA lyase (AtHPCL) involved in phytol metabolism in Arabidopsis. Plant J. 109, 1290-1304, doi:10.1111/tpj.15632
Laschke L., Schütz V., Schackow O., Sicker D., Hennig L., Hofmann D., Dörmann P., Schulz M. (2022) Survival of plants during short-term BOA-OH exposure: ROS related gene expression and detoxification reactions are accompanied with fast membrane lipid repair in root tips. J. Chem. Ecol. 48, 219-239, doi:10.1007/s10886-021-01337-z
Zietzer A., Jahnel A.L., Bulic M., Gutbrod K., Düsing P., Hosen M.R., Dörmann P., Werner N., Nickenig G., Jansen F. (2022) Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides. Cell. Mol. Life Sci. 79, 48, doi:10.1007/s00018-021-04049-5
Brands M., Dörmann P. (2022) Two AMP-binding domain proteins from Rhizophagus irregularis involved in import of exogenous fatty acids. Mol. Plant Micr. Int. 35, 464-476, doi:10.1094/MPMI-01-22-0026-R
Bleffert F., Granzin J., Caliskan M., Schott-Verdugo S., Siebers M., Thiele B., Rahme L., Felgner S., Dörmann P., Gohlke H., Batra-Safferling R., Jaeger K.-E., Kovacic F. (2021) Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa. eLife 11:e72824, doi:10.7554/eLife.72824
Girel S., Schütz V., Bigler L., Dörmann P., Schulz M. (2022) Bioactive nitrosylated and nitrated N-(2-hydroxyphenyl)acetamides and derived oligomers: An alternative pathway to 2-amidophenol-derived phytotoxic metabolites. Molecules 27, 4786, doi:10.3390/molecules27154786
Cui J., Hölzl G., Karmainski T., Tiso T., Kubicki S., Thies S., Blank L.M., Jaeger K.-E., Dörmann P. (2022) The glycine-glucolipid of Alcanivorax borkumensis is resident to the bacterial cell wall. Appl. Environm. Microbiol. 23;88(16):e0112622, doi.10.1128/aem.01126-22
Gutbrod P., Reichert S., Gubrod K., Hamai, A., Bréhélin C., Ngando-Ebongue G., Dörmann P. (2021) Fatty acid isoprenoid alcohol ester synthesis in fruits of the African Oil Palm (Elaeis guineensis) Phytochemstry 185, 112684. doi:10.1016/j.phytochem.2021.112684
Gutbrod P., Yang W., Grujicic G.V., Peisker H., Gutbrod K., Du L.F., Dörmann P. (2021) Phytol derived from chlorophyll hydrolysis in plants is metabolized via phytenal. J. Biol. Chem. 296:100530. doi:10.1016/j.jbc.2021.100530
Vanbrabant K., Van Meel D., Kerksiek A., Friedrichs S., Dubbeldam M., Schepers M., Zhan N., Gutbrod K., Dörmann P., Liu H.-B., Mulder M.T., Vanmierlo T., Lütjohann D. (2021) 24(R,S)-saringosterol - from artefact to a biological medical agent. J. Steroid Biochem. Mol. Biol. 212, 105942, doi:10.1016/j.jsbmb.2021.105942
Moseler A., Kruse I., MacLean A., Pedroletti L., Franceschetti M., Wagner S,. Wehler R., Fischer-Schrader K., Poschet G., Wirtz M., Dörmann P., Hildebrandt T.M., Hell R., Schwarzländer M., Balk J., Meyer A.J. (2021) The function of glutaredoxin GRXS15 is required for lipoyl-dependent dehydrogenases in mitochondria. Plant Physiol. 186, 1507–1525, doi:10.1093/plphys/kiab172
Wewer V., Peisker H., Gutbrod K., Al-Bahra M., Menche D,. Ngongeh Amambo G., Fombad F.F., Njouendou A.J., Pfarr K., Wanji S., Hoerauf A., Dörmann P. (2021) Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon. Paras. Vect. 14, 397. doi:10.1186/s13071-021-04893-1
Müller‐Schüssele S.J., Wang R., Desirée D., Gütle D.D., Romer J., Rodriguez‐Franco M., Scholz M., Buchert F., Lüth V.M., Kopriva S., Dörmann P., Schwarzländer M., Reski R., Hippler M. and Meyer A.J. (2020) Chloroplasts require glutathione reductase to balance reactive oxygen species and maintain efficient photosynthesis. The Plant J. 103, 1140-1154. doi: 10.1111/tpj.1479122222
Gutbrod P., Gutbrod K., Nauen R., Elashry A., Siddique S., Benting J., Dörmann P. and Grundler F.M.W. (2020) Inhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes. Sci. Rep. 10, 12710. doi:10.1038/s41598-020-69624-53333
Aizouq M., Peisker H., Gutbrod K., Melzer M., Hölzl G. and Dörmann P. (2020) Triacylglycerol and phytyl ester synthesis in Synechocystis sp. PCC6803. Proc. Natl. Acad. Sci. USA 117, 6216-6222 doi:10.1073/pnas.19159301174444
Brands M., Cahoon E.B. and Dörmann P. (2020) Palmitvaccenic acid (Δ11-cis-hexadecenoic acid) is synthesized by an OLE1-like desaturase in the arbuscular mycorrhiza fungus Rhizophagus irregularis. Biochemistry 59, 1163-1172. doi:10.1021/acs.biochem.0c000515555
Woeste M.A., Stern S., Raju D.N., Grahn E., Dittmann D., Gutbrod K., Dörmann P., Hansen J.N., Schonauer S., Marx C.E., Hamzeh H., Körschen H.G., Aerts J.M.F.G., Bōnigk W., Endepols H., Sandhoff R., Geyer M., Berger T.K., Bradke F. and Wachten D. (2019). Species-specific differences in non-lysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations. J. Biol. Chem. doi:10.1074/jbc.RA118.00631188
Patwari P., Salewski V., Gutbrod K., Kreszies T., Dresen-Scholz B., Peisker H., Steiner U., Meyer A.J., Schreiber L. and Dörmann P. (2019) Surface wax esters contribute to drought tolerance in Arabidopsis. The Plant J. 1-18 doi: 10.1111/tpj.1426999