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Regulation of lipid synthesis in bacteria

Dr. Georg Hölzl

Similar to plants, some bacteria can change their membrane lipid composition by accumulating glycolipids and other non-phosphorous lipids under phosphate deprivation. These lipids include galactolipids and glucolipids, betain lipids (DGTS, diacylglycerol trimethylhomoserine) and ornithine lipid. We recently detected novel forms of glycolipids and ornithine lipid in Agrobacterium tumefaciens (a plant pathogen bacterium employed for plant transformation) (Geske et al., 2013; Semeniuk et al., 2014), and in Mesorhizobium loti (nodulation bacterium of Lotus japonicus) (Devers et al., 2011). We are currently testing additional genes involved in the regulation of lipid synthesis in these two bacteria using a knock-out mutant strategy.

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